Reverend Monsignor William Ralph Harvey, founding pastor, worked closely with the Sisters of St. Joseph of Carondolet in staffing the school. Sister Georgeann O’Brien was named the first principal. She was succeeded by Sister Michael Ellen McEver in September 1968, at which time the school consisted of grades one through eight. In the fall of 1974, Sister Michael Flaherty was appointed principal. Sister Linda Nicholson came to Our Lady Queen of Angels School in September 1978. Kindergarten was added to the school in September 1983.
Reverend Monsignor Michael Driscoll succeeded Monsignor Harvey. In 1984 Monsignor William McLaughlin became pastor of Our Lady Queen of Angels. In September 1985, Sister Joanne Clare Gallagher was appointed principal. In August 1987, Miss Eileen Ryan joined the administration as vice-principal. In August 1988, Miss Eileen Ryan joined Sister Joanne Clare as principal.
Preschool was added in September 1991. The new wing which houses computer and science labs, music/extended day, kindergarten, and preschool classrooms, library, and school offices was opened in October 1991. The old school offices were refurbished and now comprise a counselor office, tutor room, and reading specialist room.
Our Lady Queen of Angels School is under the supervision of the Department of Catholic Education of the Diocese of Orange.